Sublingual Immunotherapy — Developed by Dr. Dat Tran, MD, FAAAAI

Retrain your immune system.
Don’t mask it.

OLLEREG is a sublingual allergy immunotherapy spray formulated by a board-certified allergist. A patented whole-mouth mist reaches five immune-active tissues in your mouth in a single dose — teaching your immune system to stop overreacting to the allergen, instead of just blocking the symptoms. Same mechanism as allergy shots. No needles, no clinic visits.

Shop Sprays

Years of OIT Science

Money-Back Guarantee

Free

Shipping Every Month

Doctor-Led

No Insurance Needed

OLLEREG Oral Spray

Pre-formulated Ships monthly Cancel anytime

Plant-Based

Glycerin solution

No Injections

Painless oral spray

Safety First

Safe. Proven.
30+ years of science.

OIT/SLIT has been used globally for decades. OLLEREG is designed with your safety at the forefront — and a health check protects every order.

Extremely well-tolerated: Most experience only mild oral itchiness. Anaphylaxis is extremely rare with sublingual delivery.
Physician developed: Every formula is developed and overseen by Dr. Dat Tran, MD, FAAAAI — board-certified allergist/immunologist.
clinical-grade extracts: Clinical-grade allergen extracts used off-label for OIT/SLIT, identical to those used in allergy shots.
Safety screening after checkout: Every customer completes our disqualification checklist after purchase. Those with contraindications receive a full refund and are directed to call our office instead.

Fox 26 Health Watch — Dr. Dat Tran on Seasonal Allergies

30+

Years of OIT research worldwide

~80%

Patients see meaningful relief

Patent-Pending Adjuvant

Unique natural formula to boost immune tolerance — found only in OLLEREG

Cancel Anytime

No commitments. No cancellation fees. Full refund within the first 90 days.

The Mechanism

Why a spray, and why it actually works

OLLEREG is sublingual immunotherapy delivered the way the oral immune system is built to receive it — as a fine mist across every mucosal surface, not pooled under the tongue. Here’s what happens inside your body.

Whole-mouth allergen dispersion

Two sprays release a fine mist that coats five tolerogenic immune tissues: sublingual, buccal (cheeks), gingival (gums), soft palate, and dorsal tongue. Drops reach one site. OLLEREG reaches all five.

Tolerogenic antigen presentation

Langerhans cells and oral dendritic cells capture the allergen within minutes and migrate to cervical lymph nodes — direct drainage, no gut degradation. There they present the allergen in a regulatory context that biases T-cells toward tolerance, not attack.

Your body switches from attack to tolerate

Over months, your immune system shifts: allergy-driving antibodies (IgE) decrease, and protective “blocking” antibodies (IgG4) rise. The protective antibodies catch the allergen before it can trigger the sneezing, itching, or congestion. Symptoms quiet because the biology upstream of them has been rewired.

Tolerance becomes durable

Your immune system grows regulatory T-cells — the cells that tell your body “this is safe, stand down.” After about 3 years of dose escalation, that tolerance signature is durable; many patients maintain relief long after stopping. Full mechanism & competitive comparison →

“The science has been ready for decades. What was missing was a delivery method that respected how the oral immune system actually samples antigen. OLLEREG is that delivery method.”
— Dr. Dat Tran, MD, FAAAAI · Board-certified allergist/immunologist

Pre-Formulated Monthly Sprays

Choose your allergy spray

Each spray is pre-formulated with clinical-grade allergen extracts. Subscribe monthly, cancel anytime. A quick health check is completed after purchase.

Woman sneezing surrounded by wildflowers

Seasonal

Pollen Relief Spray

For tree, grass & weed pollen — the leading cause of seasonal allergies across Texas and the South.

OakRagweedBermudaCedarTimothy

$75

$25

/mo for first year

Free shipping · 90-day money-back guarantee

SecureFree Ship90-Day Guarantee

Year-Round

Pet Dander Spray

Don't give up your pets. Build tolerance to dog and cat dander — the most common indoor year-round allergen.

DogCat

$75

$25

/mo for first year

Free shipping · 90-day money-back guarantee

SecureFree Ship90-Day Guarantee

Perennial

Indoor Allergen Spray

For dust mites and mold — triggers behind perennial congestion, worsened asthma, and chronic sinusitis.

Dust MiteMoldCockroachMouse

$75

$25

/mo for first year

Free shipping · 90-day money-back guarantee

SecureFree Ship90-Day Guarantee

Physician-Formulated

Custom Spray

Get a spray formulated specifically for your allergy test results. Dr. Tran creates a personalized blend targeting your exact allergen profile.

Custom BlendAllergy Test BasedPhysician Consultation

$50

/mo starting

Contact for details · Free shipping · 90-day money-back guarantee

Call for Details

Best Value

All-in-One Complete Bundle

The complete OLLEREG regimen — pollen, pet dander & indoor allergens in one comprehensive monthly subscription. Ideal for multi-allergen sufferers.

Save $94/month vs. individual sprays

PollenPet DanderIndoor Allergens

$150

$50

/mo for first year

Free shipping · 90-day money-back guarantee

SecureFree Ship90-Day Guarantee

All products use allergen extracts off-label for OIT/SLIT · Supervised by Dr. Dat Tran, MD, FAAAAI · Questions? Email us

Is it safe for kids?

Yes — OLLEREG is safe for children as young as 3. A parent or guardian completes the health check and supervises daily administration.

How long until I see results?

Many patients notice improvement within 3-6 months. We offer a 90-day money-back guarantee so you can try it risk-free.

Simple Process

Up and running in three steps

No clinic. No waiting room. No needles. Subscribe, complete a quick health check, and your spray ships every month.

Choose Your Spray

Select your allergen type. Complete a 2-minute safety checklist to confirm you're a good candidate for at-home OIT.

Receive Monthly Doses

Your spray ships free every month, automatically stepping up to a higher allergen concentration to build tolerance over time.

Breathe Easier

Two sprays once a day, wait 5 minutes before eating. Most patients notice improvement in 3-6 months. Maintenance for 3 years = lasting relief.

What We Treat

Every allergy. One spray.

OLLEREG sprays cover the most common environmental allergens.

Tree Pollen

Seasonal tree allergies lasting months — nose, eyes, lungs.

OakBirchCedarMaple

Grass & Weed

Bermuda, ragweed — dominant Texas triggers in spring and fall.

BermudaRagweedTimothy

Pet Dander

Cat and dog dander persisting year-round, even after pets leave.

DogCat

Indoor Allergens

Dust mites and mold worsening asthma, sinusitis, and eczema.

Dust MiteMoldCockroach

Asthma & Sinusitis

Allergen desensitization reduces allergen-triggered asthma flares.

AsthmaSinusitisEczema

Mechanism vs. Alternatives

Same tolerance science as allergy shots. Without the clinic, without the needles.

Nasal sprays and antihistamines suppress the allergic cascade after it fires. OLLEREG retrains the immune system upstream of it — the same mechanism as allergy shots, delivered to the mucosal tissue that was designed to induce tolerance.

Feature

Recommended OLLEREG

Daily Nasal Sprays

Allergy Shots

Builds lasting immune tolerance Key difference
✓Retrains the immune system over time
✗Suppresses inflammation only, no immune change
PartialRequires 3–5 years of weekly clinic visits

100% at-home treatment

✓

✗Clinic visit every week for 3–5 years

No injections / painless

✓2 oral sprays daily (morning & evening)

PartialNo injections but may cause dryness & nosebleeds long-term

✗Injections every visit, risk of anaphylaxis

Safe for young children

✓Ages 3+, physician supervised

PartialAge minimums vary; not all formulas approved for young kids

✗Weekly injections, not recommended under 5

No clinic visits required

✓Online health check only

✓OTC, no appointment needed

✗Must stay at clinic 20–30 min after every injection

Physician developed & supervised

✓Dr. Dat Tran MD, board-certified allergist/immunologist

✗OTC, no medical supervision

✓

Escalating doses build tolerance Key difference
✓Monthly dose escalation, same science as shots
✗Fixed dose, no tolerance mechanism
PartialRequires years of injections to achieve

Free shipping to your door

✓

✗Pharmacy pickup only

✗Clinic-administered only

Typical annual cost

~$300/yrFirst year at $25/moThen ~$900/yr ($75/mo)

$200–360/yrIndefinite ongoing expense

$1,500–$4,000/yrPlus time off work for weekly appointments

Daily nasal spray costs based on average OTC retail pricing. Allergy shot costs include published estimates for serum and administration fees and do not include copays or time costs. Individual results vary. Consult a healthcare provider before changing any medication.

Real People. Real Relief.

Join hundreds of families breathing easier with OLLEREG.

Teen enjoying outdoors with OLLEREG spray

★★★★★

"I can actually enjoy being outside during spring now. No more hiding indoors when the pollen count is high."

Before: Constant sneezing, watery eyes, and misery every spring and fall. OTC meds barely helped.

— Sarah T., Austin, TX

★★★★★

"My daughter can finally have sleepovers without us worrying about her allergies acting up."

Before: She missed so many activities because of allergy flare-ups. We hated watching her sit out.

— Maria L., Houston, TX

Man with his golden retriever, holding OLLEREG spray

★★★★★

"My golden retriever can finally sleep in the bedroom again. OLLEREG changed everything for our family."

Before: Couldn't be in the same room as my dog without sneezing. Almost had to rehome him.

— Marcus D., San Antonio, TX

Individual results may vary. Testimonials reflect the experiences of these customers and are not guaranteed.

Track Your Progress in the OLLEREG Portal

Most allergy treatments leave you guessing. OLLEREG gives you a free patient portal to track your symptoms month over month — so you can actually see your allergies getting better.

Monthly Symptom Surveys

Rate your symptoms each month. Takes under 2 minutes. See your scores trend downward as your immune system builds tolerance.

Visual Progress Charts

See your allergy scores plotted over time. Share your progress with your doctor. Real data, not guesswork.

Direct Support Messaging

Have a question? Message the OLLEREG team directly through the portal. No phone trees, no waiting rooms.

FAQ

Common questions

Are these sprays pre-formulated or custom?

The shop sprays are pre-formulated for each allergen category using standard clinical concentrations. For a fully customized formula based on your specific allergy test results, contact us directly for a physician consultation.

How do I take OLLEREG?

Two sprays once a day under your tongue. Wait 5 minutes before eating or drinking — it takes under a minute.

How long until I see results?

Many patients notice improvement within 3-6 months. Maintenance dose is reached at ~6 months and treatment continues for a minimum of 3 years for durable long-term relief.

Can I give OLLEREG to my child?

Yes — OLLEREG is safe for children, with patients as young as 3 using it successfully. A parent or guardian must complete the health check and confirm they will supervise administration.

Who should NOT use OLLEREG?

People with a history of anaphylaxis, severe uncontrolled asthma, those who are pregnant, on immunosuppressants, or on beta-blockers should not self-administer. Our post-purchase health check will flag these conditions — you'll receive a full refund and be directed to call our office instead.

What is the cancellation and refund policy?

Cancel your subscription at any time — no fees. OLLEREG offers a 90-day money-back guarantee because real results from immunotherapy take time. Use it for 90 days, and if you're not satisfied, we'll refund you in full.

What is OIT and how does OLLEREG work?

OIT (oral immunotherapy) retrains your immune system by exposing it to tiny, increasing doses of an allergen. OLLEREG delivers this under your tongue, where special immune cells absorb it safely. Over months, your allergy-driving antibodies (IgE) decrease while protective antibodies (IgG4) rise — building lasting tolerance. Learn more about the science →

Meet the Doctor

Invented by an allergist, for allergy sufferers

Dat Tran, MD, FAAAAI

Medical Director

Dr. Tran is a board-certified allergist/immunologist. He did his fellowship training at the National Institutes of Health and pediatric residency at Texas Children's/Baylor College of Medicine. He was a former tenured associate professor at UTHealth McGovern Medical School. He left academia and opened Innovative Allergy, PLLC in 2017 with a mission to efficiently care and treat patients with innovative approaches. He invented Ollereg as a convenient, painless treatment for environmental allergy, EatFreely OIT to cure food allergy, and Esoygen to treat hormonal imbalance. He is continuously researching to develop novel treatments and continues to be active in research.

Facebook LinkedIn

Founder & Medical Director of Innovative Allergy — 6+ locations across Houston. ★★★★★ 5.0 · 300+ Google Reviews. See the clinic →

Get in Touch

Contact us

Have questions about OLLEREG, your subscription, or whether immunotherapy is right for you? We're here to help.

Call Us

(346) 232-2993
Mon-Fri, 9am-5pm CT

Email Us

order@ollereg.com
We typically respond within 24 hours

Visit Our Office

Innovative Allergy
6550 Mapleridge St Ste 115
Houston, TX 77081
View on Google Maps →

Physician Consultation

Need a custom formula or have complex allergies?
Schedule a consultation with Dr. Tran.

Retrain your immune system.
Don’t mask it.

Safe. Proven.
30+ years of science.