Frequently Asked Questions

OLLEREG is a physician-developed oral immunotherapy spray that delivers small, controlled doses of allergen extracts under the tongue. Over time, this retrains the immune system to tolerate allergens instead of overreacting — the same science behind allergy shots, without the needles or clinic visits. All products are supervised by Dr. Dat Tran, MD, a board-certified allergist/immunologist.

The shop sprays (Pollen, Pet Dander, Indoor Allergen) are pre-formulated for each allergen category using standard clinical concentrations. For a fully customized formula based on your specific allergy test results, contact us directly for a physician consultation with Dr. Tran.

Pollen Relief Spray: Oak, ragweed, Bermuda grass, cedar (mountain cedar/Juniperus ashei), and timothy grass. Pet Dander Spray: Dog, cat, horse, and rabbit dander. Indoor Allergen Spray: Dust mites, mold, cockroach, and mouse allergens. The All-in-One Bundle includes all three sprays for multi-allergen sufferers.

No — the pre-formulated sprays are designed to cover the most common allergens in each category. If you know what triggers your symptoms (pollen season, pets, indoor congestion), you can select the right spray. If you want a formula tailored to your exact allergy test results, the Custom Spray option requires a physician consultation.

Spray 1-2 times under your tongue daily and wait 5 minutes before eating or drinking. Morning or anytime during the day — it takes under a minute. Hold the spray under your tongue for best absorption.

Many patients notice improvement within 3-6 months. Maintenance dose is reached at approximately 6 months. For durable, long-term tolerance that lasts after stopping treatment, a minimum of 3 years of consistent use is recommended — consistent with international allergy guidelines for immunotherapy.

OLLEREG follows a monthly dose escalation protocol — starting with a lower concentration and gradually increasing over several months. This allows your immune system to adjust safely and build tolerance progressively. Each monthly shipment contains the appropriate concentration for your stage of treatment.

Yes. OLLEREG can be used alongside antihistamines, nasal sprays, and other standard allergy medications. Many patients continue using their existing medications during the first few months and gradually reduce them as tolerance builds. Do not stop any prescribed medication without consulting your doctor.

Missing one day occasionally is fine — just resume your normal schedule the next day. If you miss several consecutive days, contact our team for guidance on whether to resume at your current dose or step back slightly. Consistency is important for building tolerance.

Yes — OLLEREG is safe for children as young as 3. A parent or guardian must complete the safety screening and supervise daily administration. Sublingual immunotherapy has been studied extensively in pediatric populations, with a meta-analysis of 42 randomized controlled trials confirming safety and efficacy in children.

People with a history of anaphylaxis, severe uncontrolled asthma, those who are pregnant, on immunosuppressants, or on beta-blockers should not self-administer. The checkout safety screening will flag these conditions and direct you to call our office instead for a physician consultation.

The most common side effect is mild oral itching or tingling under the tongue during the first few weeks. This typically resolves as your body adjusts. Some patients also experience minor throat irritation or mild mouth swelling. Serious systemic reactions are extremely rare with sublingual immunotherapy — clinical trials involving thousands of patients report no fatalities and significantly fewer adverse events than allergy shots.

OLLEREG uses FDA-approved allergen extracts that are used off-label for oral immunotherapy (OIT/SLIT). Off-label use of approved medications is a well-established, legal practice in medicine. All OLLEREG products are developed and supervised by Dr. Dat Tran, a board-certified allergist/immunologist with the American Board of Allergy and Immunology.

Before completing your purchase, you'll answer a short set of medical screening questions. This ensures you don't have conditions that make self-administered immunotherapy inappropriate (severe asthma, history of anaphylaxis, etc.). If the screening flags a concern, you'll be directed to call our office for a direct physician consultation instead.

Individual sprays (Pollen, Pet Dander, or Indoor Allergen) start at $25/month for the first year, then $97/month. The All-in-One Bundle (all 3 sprays) starts at $49/month for the first year, then $197/month — saving $94/month vs. buying individually. Custom sprays start as low as $50/month — contact us for details. Free shipping is included on every order.

Cancel your subscription at any time — no fees, no questions asked. OLLEREG offers a 90-day money-back guarantee because real results from immunotherapy take time. Use it for 90 days, and if you're not satisfied, we'll refund you in full.

Your first spray ships within 2-3 business days of completing your order and safety screening. After that, your monthly refill ships automatically — with the appropriate dose escalation for your treatment stage. Shipping is always free.

OLLEREG is not currently billed through insurance. However, many patients find it significantly more affordable than allergy shots when factoring in copays, clinic visit costs, and time off work. You may be able to use HSA or FSA funds — check with your plan administrator.

OLLEREG uses the same immunotherapy science as allergy shots — gradually exposing the immune system to build tolerance. The difference is delivery: a painless oral spray at home vs. weekly injections at a clinic. No needles, no 20-minute post-injection waiting periods, no time off work. Research shows sublingual immunotherapy achieves comparable long-term outcomes with significantly fewer systemic side effects.

Daily nasal sprays (corticosteroid or antihistamine) suppress allergy symptoms but do not change the underlying immune response. When you stop using them, symptoms return — often worse than before. OLLEREG retrains the immune system to build lasting tolerance. It's the only treatment approach recognized by the World Allergy Organization as modifying the underlying allergic disease.

Many patients transition from allergy shots to sublingual immunotherapy. If you're currently receiving shots, we recommend discussing the transition with your allergist. The safety screening will ask about your current treatment so we can ensure a safe switch. Contact our office at 346.232.2993 if you have questions about transitioning.

Antihistamines block one part of the allergic response (histamine) but do not change your immune system's sensitivity to allergens. You'll need them every season, potentially for life. OLLEREG works to resolve the underlying problem so your immune system eventually stops overreacting — with the goal of reducing or eliminating the need for daily medication.